<address id="xbldl"></address>

          <sub id="xbldl"><mark id="xbldl"><mark id="xbldl"></mark></mark></sub>

              雨楓軒原創文學網 - 純凈的綠色文學家園 !

              雨楓軒

              日本攻克白血病?這種鬼話你也信?

              時間:2019-08-27來源:網友提供 作者:俞天任 點擊:
              日本攻克白血病?這種鬼話你也信?

                
                海外華人都有過這樣的經驗:在看了一些自媒體的文字之后,不由得開始懷疑:自己是不是身在一個假美國、假日本或者假歐洲國家?為什么那些自媒體搞出來的新聞,跟我們的所見所聞差距那么大?
                
                比如這些天有一篇四處刷屏、說《日本宣布攻克白血病》的東西,就是這樣。
                
                這篇東西似乎最早是東京的一個華人自媒體發出,可能沒有聲明原創,接下來就是各種二手山寨加盜版侵權,反正到處都能看到。
                
                就不知道那些盜版侵權的二手自媒體知道不知道:這條消息其實是在胡扯。
                
                理由一:日本沒這個能力
                
                日本確實是一個發達國家,有不少世界領先的領域。日本的醫藥很有意思,日本的醫療水平很高,醫療制度更好,但制藥工業卻很一般。到現在為止,日本還沒有開發出來過什么了不起的藥品,說起制藥,那還是美國、德國和瑞士。
                
                日本的醫藥公司除了購買歐美的專利生產之外,就是生產專利已經失效了的藥品,所謂通用名藥物(generic medicine)。日本自己的藥物可能就是賣給中國游客的漢方藥物了,什么引人注目的“日本藥品”?不存在的。
                
                日本從美國進口的大宗商品中的5.2%是飛機,接下來就是5.1%的醫藥品了,2018年為4757億日元。
                
                所以筆者一看到“日本宣布攻克白血病”這幾個字就本能地懷疑——日本,它就沒這個能力呀。
                
                理由二:看看日本新聞怎么報道的
                
                接下來這個自媒體又抬出來了諾貝爾獎得主本庶佑,這就讓筆者更加懷疑了,因為雖然本庶佑教授的獲獎理由還真是因為“在發現負性免疫調節治療癌癥的療法方面的貢獻”,而且已經商品化成功,但是本庶佑教授主攻的方向是黑色素瘤,并不是白血病。
                
                再看下去就知道這場烏龍的由來了。日本厚生勞動省在2019年5月15日決定了一種叫“Kymriah”的藥在日本的售價,并且接受中央社會保險醫療協議會的建議,將其納入全民健康保險。
                
                但那個自媒體公眾號不知道這種藥品是美國開發、瑞士制造的,可能因為藥品是由那家瑞士制藥公司的日本法人銷售,就以為是日本開發的了。
                
                “Kymriah”是這種藥物的商品名,實際上的名字叫“Tisagenlecleucel”。是美國賓夕法尼亞大學的卡爾·尤恩(Carl H. June)教授帶領的研究小組發現的,由瑞士的諾華(Novartis)公司商品化,2017年8月得到了美國FDA承認,在美國使用。
                
                其實把“Kymriah”說成是一種療法可能更合適。這是一種遺傳基因療法,把患者血液中的T細胞取出來,將其中的遺傳因子修改為帶攻擊癌細胞能力之后再回送患者體內。
                
                這種藥在美國的市場價是47.5萬美元,日本的市場價為3349萬日元,雖然低于美國市場,但單次使用就需要花費幾乎200萬人民幣的藥價也使得非大富大貴人家無法問津,這才納入了全民健康保險。
                
                為什么日本市場價比美國市場價便宜?理由是“Kymriah”在美國的使用方式很奇葩:和老時候賣大力丸一樣,“不好不要錢”——治好了之后才收錢,沒治好就算了。而日本人測算下來這種藥物的療效在83%左右,所以就比美國便宜下來了。
                
                所以,這種藥本身和日本就沒有關系,當然白血病也還沒有被最后攻克。
                
                如果一定要把這種藥和日本扯上關系的話,就是也在日本進行了一部分臨床實驗。
                
                但對于日本患者來講,不需要標題黨的夸張說法,這項政策倒確實是個善政。
                
                日本患者得到的真實保障
                
                當然,全民健康保險也要有人買單,而現在日本的全民健康保險已經是赤字了,隨著社會人口的進一步老齡化,赤字還可能進一步擴大,隨意引進這么高價的藥物能行嗎?
                
                但事實是,雖然這種藥物非常昂貴,但實際上倒并不增加多少全民保險的負擔,因為能用的人很少,因為根據《日本經濟新聞》2019年5月14日的報道,日本全國能夠用上這種藥的每年也就只有250人左右。
                
                日本的白血病發病率是萬分之6.3左右,也就是說每年大約有7萬人患白血病,怎么只有250人用這種藥呢?
                
                “白血病”是一個非常復雜的概念,簡單地說可分為“急性”和“慢性”,還可以分為“骨髓”和“淋巴”,這就有了“急性淋巴”、“急性骨髓”、“慢性淋巴”、“慢性骨髓”等四種了。而Kymriah療法僅僅對“朝囊定位細胞”(bursa oriented cells,也稱B細胞)性的急性淋巴白血病有效,有效率如前所說,為83%。
                
                83%的治療率是不是很了不起呢?
                
                白血病聽起來嚇人,像當年日本電視劇《血疑》里的悲劇更加劇了人們的恐懼,實際上白血病的治愈率并不低。一般來說發病5年后不再復發就算治愈,對于主要患者群是年輕人的急性淋巴白血病來說,治愈率一直就在80%以上。這次Kymriah的話題其實并不在療效上,而在于全民保險制度居然引進了這么昂貴的藥物。但考慮到這種藥的應用范圍相當狹窄,也就可以理解了。
                
                引入全民健康保險之后,雖然患者只需負擔30%,但對于這么昂貴的藥物來說,30%也是很可觀的數字,一次用藥就超過7萬人民幣的藥費,也不是大多數人能夠負擔的。所以問題來了,這種“保險”會不會變得有名無實?
              頂一下
              (0)
              0%
              踩一下
              (1)
              100%
              ------分隔線----------------------------
              發表評論
              請自覺遵守互聯網相關的政策法規,嚴禁發布色情、暴力、反動的言論。
              評價:
              用戶名: 驗證碼: 點擊我更換圖片
              幸运时时彩幸运时时彩app www.fa365b.com | www.890655.com | cr883.com | www.ihg5555.com | xpj55663.com | 86067.com | www.99788k.com | www.xpj5808.com | bmw6.tv | www.68666m.com | www.186055.com | www.565522f.com | 6403pp.com | ylg4488.net | 30987t.com | www.5860s.com | www.pb0999.com | www.25688j.com | d70266.com | www.17933b.com | www.6552233.com | www.252599u.com | www.n7720.net | 3333yh.com | www.c89077.com | xian1188.com | www.hg894.com | 526269.com | www.xpj18988.com | www.hg8862.com | www.gyfc9.com | www.n333266.com | 278365365.com | www.hv866.com | x33375.com | 7676011.com | www.9139a.com | 28111a.com | 88jt066.com | www.22js66.com | www.yl6630.com | mgm8536.com | www.xpj5005.com | www.pu335.com | www.3399410.com | 1111zx.com | www.hv65.com | v55998.com | www.52303g.com | www.js60055.com | 00660040.com | www.944229.com | www.j5158.com | j45638.com | www.39957e.com | www.88110151.com | rb498.com | www.h1099.com | www.5003iii.com | www.764173.com | 20160913.in | 340388.com | 99796y.com | 8167g.com | 38545555.com | a5089.com | www.702152.com | www.j6799.com | n7727.com | www.022194.com | www.334268.com | wd9033.com | www.712089.com | www.6556u.com | www.hg9757.com | www.rui33.com | 300msc.com | www.36544bet.com | www.219585.com | www.719113.com | 321880.com | www.707595.com | hg068.biz | www.75044.com | www.yh25558.com | 336688l.com | 8886hj.com | hg70338.com | 98ts88.com | www.h7788v.com | 48588f.com | www.bmw000999.com | www.bet3666.com | www.520898.com | vns8893.com | www.66710.cc | 01512211.com | www.00770040.com | www.979816.com | 56733n.com | www.zx988.com | zr7766.com | dzc8777.com | 278xj.com | www.177864.com | www.5555287.com | www.485060.com | www.8820js.com | 95990555.net | www.777306.com | 730665.com | www.48289999.com | www.7728229.com | 858vn.com | www.66508006.com | hm916.com | www.44466638.com | 155004.com | v5662.com | 88837t.com | www.pj8843.com | hg0980.com | www.907883.com | 453066.com | 1720a.com | 18866004.com | 006087.com | www.34567cc.cc | 189365.com | www.k1668.com | www.53516l.com | www.ty611.com | pj33440.com | www.600hc.com | www.js06657.com | www.023223.com | hc948.com | www.695395.com | www.877585.com | vns82288.com | www.583792.com | www.80408877.com | www.hg44958.com | 276565.com | www.071wy.com | www.88js22.com | www.xy470.com | www.399941.com | www.9996aa.com | www.pj939.com | ssbo66.com | 7966xxx.com | www.4zhizun.com | www.20074422.com | www.68280.cc | www.96386u.com | lll5002.com | 99950001.com | 023452.com | www.746133.com | www.00660040.com | www.sb5878.com | 813993.com | www.c9259.com | www.aa0151.com | yh38838.com | wap.8vp88.com | www.fei27.com | www.1253cc.com | www.hh638.com | 36513.cc | www.730979.com | www.9999vn77.com | hg15567.com | 4440365.com | www.19czj.com | www.735677.com | yl.6175514.com | www.longhu006.com | www.424277.com | www.114937.com | 24999ee.com | 111658.com | www.954321x.com | 035841.com | 4283.cabet310.com | www.139964.com | www.535520.com | www.01512299.com | www.555aamm.com | bet7988.com | www.899495.com | wn777.co | www.hg87458.com | www.331098.com | www.465956.com | www.21365mm.com | www.788.xxx | www.xhtd883.com | 660726.com | www.ya2019b.com | www.7366009.com | www.hj9902.com | wh216.com | www.404577.com | www.541897.com | www.sb8822.com | www.521045.com | www.cao880.com | 882996.com | www.9599882.net | wnsr64.com | www.216781.com | www.xpj682.cc | www.mgm0018.com | vns6196.com | www.13718307455.com | www.621155c.com | ff9702.com | www.hgdc888.net | bg206.com | www.hm2277.com | www.i4116.com | www.809977.com | 67847b.com | 0399456.com | zs1199.com | www.333808e.com | cx8811.com | www.mcqgxdmr.com | www.975961.com | 496ooo.net | 1110dhy.com | lehu819.com | www.yh6556.com | www.5335kk.com | wt488.com | www.130546.com | www.2418000.com | ab291.com | www.1235503.com | 3000023.com | www.2000226.com | www.09082.com | www.pjw36.com | www.347887.com | 3339p.com | www.55766.com | www.amyl364.com | www.ls0022.com | www.528802.com | js70699.com | youfa271.com | www.544090.com | 5678147.com | 10611.cc | www.45335.com | www.491989.com | www.8901ee.com | www.796499.com | 396655.com | www.374511.com | a7727.cc | ven4444.com | www.ca373.com | 9m12.com | www.506257.com | 3782o.com | p2005.com | www.519025.com状态:OK | 5534399.com | www.843881.com | www.wn99v.com | www.805077.com | 54443000.com | www.461746.com | www.72002.com | bet0077o.com | www.p17777.com | 4111nnn.com | weide5555.com | www.2875g.com | www.045588.com | www.60855005.com | www.2229ll.com | zd515.com | btt-59.com | www.777444i.com | 56733u.com | www.hg7741.com | www.2015.am | www.353073.com | www.59901.com | 88jsxs.com | www.zz378.com | cr779.com | www.betss365.com | www.g2251.com | www.954321i.com | www.678919.biz | www.xiao8.xpjdc.cc | www.671799.com | 97999a.com | www.49956v.com | 38345l.com | www.y822211.com | www.305895.com | www.507216.com | www.7779365.com | 9150000.com | www.dd9988.com | www.734900.com | 604607.com | 6648m.com | 198207.com | www.4469.cc | www.00699a.com | www.w8066.com | www.xx9927.com | 30500900.com | www.03619.com | vvvv0066.com | www.39957d.com | pj1707.com | www.js66673.com | 970bet.com | www.848099.com | 9997388.com | www.68568j.com | www.388307.com | www.329006.com | 030j.net | vnsr396.com | 8900365.com | www.77803x.com | www.e13608.com | w6680.com | www.389620.com | www.537217.com | yifa26.com | bet36255.com | www.495655.com | 310716.com | www.9927jjj.com | zr99999.com | hg40567.com | www.66463a.com | www.lczg5.com | www.9374p.com | 155436.com | 50cqgj.com | ff3189.com | www.ll36590.com | www.u15666.com | www.62118c.com | 8148.com | www.js22513.com | www.678450.com | www.95992244.com | wnsr264.com | hm764.com | www.022j.cc | www.kim111.com | www.2306.net | q553066.com | www.yzc956.com | www.057357.com | www.461446.com | www.762933.com | www.99927nn.com | www.v84.com | 535499.com | 255599.com | www.07142004.com | www.bm662.cc | www.hf259.com | www.624880.com | www.ks1384.com | 2100005.com | sky288.com | 58557l.com | www.33662138.com | 3650026.com | www.308626.com | www.065766.com | www.443344.com | www.6403oo.com | www.vns9915.com | 384600.com | xpj88807.com状态:OK | www.88337m.com | www.688114.com | www.50064c.com | 7334ss.com | v3190.com | www.22008678.com | 899782.com | cx9875.com | 4107r.com | rb684.com | www.m98666.com | www.76520p.com | 748551.com | www.0152hh.com | 0138p.com | www.yh55519.com | 130677.com | www.444557.com | www.611434.com | sbf857.com | www.904862.com | 334msc.com | www.j89ii.com | www.wn629.com | www.594132.com | www.01266c.com | xjs3688.com | www.bet787i.com | hdc100.com | 19880j.com | www.369158.com | www.wn2058.com | vns9218.com | 844859.com | www.4003838.com | www.yh8374.com | www.34567bb.cc | bt309.com | 25333.net | 0625014.com | www.770960.com | 3122oo.com | www.myi2265.com | www.15688001.com | www.6786622.com | www.60855999.com | www.774792.com | www.39360.com | 11172222.com | www.ym266.com | 6131313.com | www.hg696969.net | hg2219.com | www.mgm3886.com | 51996.com | 287338.com | js11221.com | www.88065c.com | www.n88msc.com | www.sts968.com | 19891212.com | www.g45638.com | k99950.com | hlf806.com | www.396830.com | zz7.tv | 612389.com | bet1365.sh | www.809572.com | www.sb5504.com | www.bc8866.com | www.13229999.com | www.30771.com | js7666.com | 035898.com | 3245i.com | www.526160.com | k37088.com | www.77336m.com | 8109988.com | www.520462.com | www.xb99.com | hg901.com | 159504.com | 130203.com | www.mgm855.com | k8dc04.com | www.19989.com状态:OK | www.657703.com | www.b2717.com | www.js9922.com | hg788.net | www.022173.com | www.81306a.com | www.6069966.com | www.95jyb1.com | www.890488.com | www.55268mm.com | www.8333v.com | www.46381.com状态:OK | 9126686.com | 33585f.com | www.yd81.com状态:OK | www.fa365e.com | yh1802.com | www.lhj6785.com | 33885002.com | www.477070.com | www.90659.com状态:OK | ao499.com | www.bet00345.com | c38ii.com | 2028365.com | www.196071.com | www.9205a.com | soxi588.com | 3846o.com | www.23418s.com | www.e1423.com | www.855168c.com | www.k94566.com | www.5207806.com | 95998800.net | 01518844.com | 5000vns.com | 365w2.com | 30555r.com | wxc644.com | www.97610.com | www.amws3399.com | www.88579d.com | 188570.com | www.802633.com | www.qj35.com | www.9205e.com | www.99677h.com | www.pj8333.com | www.hg1005.com | www.bet3650077.com | js882288.com | 53516aa.com | 19933of.com | www.ao2016.com | rb9990.com | www.rui333.com | www.oo8040.com | www.338785.com | www.459262.com | mgm1834.com | www.399150.com | www.5958115.com | www.yh8434.com | 13869999.com | 621323.com | 7979kk.net | vns6263.com | www.1076009.com | yh5677.com | www.88jt00009.com | 0745544.com | www.30157700.com | 362086.com | 60js333.com | vns00777.com | 231558.com | www.612503.com | www.4776666.com | www.277372.com | www.369946.com | www.746909.com | www.19829d.com | www.wnsr63.com | 305000.com | kb8832.com | d72555.com | heji138.com | 8746922.com | 7141nn.com | www.0652002.com | www.yh727a.com | www.4018s.com | www.55885o.com | www.325771.com | www.356776.com | www.764499.com | www.979819.com | www.902261.com | www.cb3788.com | www.7116c.com | www.2350n.com | www.3933p.cc | www.770001.com | www.967699.com | www.910977.com | www.890752.com | www.hm6333.com | www.1248g.cc | www.zuan444.com | www.923076.com | www.742255.com | www.756202.com | www.546868.com | www.755901.com | www.909644.com | www.663948.com | www.371957.com | www.h7788p.com | www.mgm070.com | www.yl3789.com | 3522b.com | www.2001166.com | sha0444.com | www.btt225.com | www.pj5902.com | www.943a29.com | 76543g.com | www.22885004.com | www.34kj.com | www.jsc044.com | www.78919g.com | www.s63568.com | www.7886276.com | www.99094h.com | www.683158.com | www.75538d.com | www.sygj1.com | www.373970.com | www.113438.com | www.80767u.com | esc488.com | www.50505066.com | www.e3467.cc | www.16660017.com | www.bg191.com | www.15273301001.com | xh8855.com | 111c788.com | www.146663344.com | www.6625359.com | www.636268.com | www.826236.com | www.sss0016.com | 3078c.com | www.yf1155.com | df5222.com | 92290z.com | www.wnsr12315.com | w2215.com | l99138.com | www.332498.com | 2767k.com | www.ylg822.com | he0077.com | www.t0088hg.com | hg50999.com | xsj700.com | www.j0678.com | 427712.com | www.2225js.com | www.57727w.com | bc218.com | 55951e.com | 5860b.com | www.js8938.com | xpj09999.com | www.sjs14.com | 551701.com | www.52333.com | www.pjzxyl.com | www.949430.com | www.602983.com | yzc551.com | d3186.com | hv168.com | www.sss0006.com | www.373031.com | 6534a.com | 877138.com | hg82282.com | www.sb5333.com | www.331830.com | www.xl300.com | www.t64602.com | www.234567l.com | www.jj0151.com | www.94565.com | 3782z.com | www.fh6000.com | www.779333.com | www.hg28866.com | www.cf9909.com | www.80767u.com | www.4915z.com | c7349.com | www.yz7988.com | www.747365e.com | www.297620.com | 454765.com | www.rb742.com | hg1812.com | www.69111d.co | www.2017.ms28.com | www.js70800.com | hlf808.com | www.288543.com | 698770.com | www.6301888.com | www.3089c.com | www.suncity3.com | 45663b.com | 909093c.com | www.hv65.com | www.860643.com | www.022i.cc | 95992277.com | www.270229.com | hgw8708.com | www.0503nn.com | js881c.com | 4681.cabet210.com | www.tm376.com | www.pj55567.com | www.3178h.com | 18890004.com | www.36896.com | 37858k.com | 012768.com | www.vns3668.cc | www.222431.com | www.116016.com | www.5187222.com | 70398u.com | www.9988gvb.com | www.09569w.com | www.71233f.com | www.188934.net | www.3126v.com | www.591799.com | www.102687.com | www.sss0089.com | www.36536598.com | 0588a.com状态:OK | yh74666.com | www.js10887.com | www.jsdc9333.com | www.0040oo.com | www.00829t.com | www.50080x.com | ag5759.com | 18866007.com | hg0689.com | 82870010.com | www.rb6543.com | 76589.com | www.00852vvv.com | 4591004.com | www.30177722.com | www.880148.com | www.349577.com | www.705081.com | 33220007.com | 362096.com | www.m5458.com | pj8445.com | 3339js.com | www.ww1423.com | www.tb186.com | www.11ttz.com | www.06868888.com | yh1809.com | 11885678.com | 9599888.cc | www.19930220.com | www.370207.com | www.bm1244.vip | www.hg8043.com | www.721560.com | www.33997r.com | 99977365.com | 65886s.com | 01819z.com | www.198924.com | hg7647.com | www.4260066.com | www.23426c.com | www.997558.com | www.41518q.com | th889900.com | 68666u.com | www.523830.com | www.tc2777.com | 2811103.com | www.ylg20000.com | www.a1a222.cc | www.9149q.com | xgsmh0.com | 455200.com | 6782c.com | www.625655.com | www.801341.com | www.6245f.com | www.617704.com | www.2350q.com | 090799999.com | yf5564.com | www.jsc9809.com | y73333.com | www.bet33365d.com | 459871715.com | www.bet365a4.com | www.768399.com | 8800042.com | www.1818809.com | 23819.com | hg3893.com | 434xpj.com | www.xpj6768.com | www.zzw222.com | www.818968.com | yf905.com | 182045.com | www.hg7911.com | www.vns6001.com | www.548787.com | www.cqbdgg.com | bg0688.com | www.252599i.com | www.393310.com | www.yh36099.com | www.6625d.com | www.pj5735.com | www.59999.am | 471677.com | www.k38999.com | 2767gg.com | www.p33366.com | www.102308.com | www.d8863.com | www.9478i.com | www.400dhy.com | www.83365m.com | 1423huang.com | www.cqgj16.com | www.jsc747.com | www.900y.com | www.324770.com | wxc877.com | js65x.com | www.hg7959.com | 5380909.com | k8927.com | www.98528h.com | www.777770907.com | 4byyz.com | www.hm1117.com | www.358888y.com | www.vns4003.com | www.ylg7777.com | js.09t.cm | yibet.cc | www.716pj2.com | www.vip9916.com | 090711111.com | www.423886.com | www.88811365.com | ca904.com | www.66224111.com | www.30350d.com | 8834808.com | www.958500.com | 676590.com | 2666365.com | www.lehu81.com | www.684255.com | www.ff93488.com | www.zzyl62.com | sbf821.com | pj0978.com | www.01266j.com | www.13822888.com | www.p24074.com | www.ban03.com | zb720.com | www.059895.com | xj922.com | 66000151.com | www.l63568.com | www.99111gg.com | 297033.cc | y88003.com | 11422a.com | www.3189b.com | www.78949w.com | www.u72555.com | 53809.com | www.cr599.com | www.77777xxx.com | vnsr388.com | blr9012.com | 39amhg.com | mgm3078.com | www.vns.online | www.xw0000.com | www.186793.com | www.373031.com | 4116a.cn | www.332690.com | www.17828m.com | www.czg7.com | 2308333.com | 4111yyy.com | www.hv88.com | www.855play.com | www.hm2777.com | www.922833.com | 14106.com状态:OK | dhy3933.com | www.949711.com | www.66621q.com | www.836236.com | 8553z.com | www.xpj7522.com | www.55615m.com | www.26299g.com | wap.md799.com | 358888d.com | www.419889.com | 5678148.com | www.808732.com | www.654525.com | www.68169a.com | www.485060.com | www.28758k.com | tbo68.com | www.995pp.net | 00789j.com | 184998.com | www.449555.com | www.aa865.com | 345864.com | www.650870.com | www.v88118.com | www.xj1992.com | sb7070.com | 2383kk.com | 2767q.com | www.65436f.com | www.51515i.com | 18365g.com | www.1469i.com | 66990151.com | www.55717q.com | www.18866005.com | www.447369.com | www.99830t.com | www.sjs06.com | www.ii6534.com | 83799.com | www.hg9809.com | yl4310.com | www.0601n.com | www.65422k.com | www.959904.net | www.xpj2808.com | qa002.com | www.843980.com | www.13082592772.com | www.7416.com | www.js81329.com | www.54mscc.com | www.88969b.com | 4138g.com | 828b.cc | 91684.com | bwin0066.com | 5146o.com | www.016980.com | www.kfan88.com | gpzzz.com | www.803317.com | www.207065.com | n6455.com | www.805835.com | 276565.com | www.468486.com | wn99oo.com | www.21202p.com | c62288.com | www.18800002.com | www.65436a.com | 659200.com | yq226.com | 6049888.com | jj733.com | www.381111.com | jz318.com | www.99796r.com | 20550599.com | www.78919h.com | jqkabet.com | 18830003.com | 88128p.com | www.pj56b.com | www.o62288.com | www.pj8668.com | 519977.com | www.ya2019h.com | www.vd97.com | yh8340.com | www.114997.com | www.5854y.cc | 796441.com | hg7825.com | 68379.net | www.355911.com | 81138q.com | 28489922.com | www.k8k8.me | www.486898.com | www.349799.com | 665524.com | www.39695h.com | 670717.com | x33371.com | 31112055.com | www.xj1996.com | www.3078n.com | www.95jyb6.com | t7276.com | www.5522s.cc | www.bet3654123.com | www.291082.com | www.vip93.com | 3038006.com | www.js6088.com | www.3ms888.com | www.x6599.com | www.51609.com | www.bmw8004.com | 155134.com | 492997.com | www.931669.com | www.251893.com | www.hd98.am | www.hg7022.com | www.yun2888.com | www.99399y.com | ii23668.com | www.381412.com | 030s.net | 1423k.com | 68228o.com | www.647006.com | vns7848.com | www-hg522.com | www.540819.com | www.018942.com | www.560703.com | www.672004.com | jsdc9777.com | www.723095.com | www.88333955.com | www.20550996.com | www.525988.com | 114597.com | www.6539888.com | www.00840f.com | 28777.com | www.771170.com | www.663189.com | 979704.com | y88003.com | www.303688.com | www.0652080.com | 1770e.com | www.888vn.com | bet1365.sh | www.17710007.com | www.h99111.com | pj6667.vip | 62226j.com | www.js9798.com | www.hb95899.com | www.2222k8.net | hx3300.com | www.qaz51.com | pj331122.com | www.yd12322.vip | 13990006.com | hg0466.com | www.j3577.com | m.99159a.com | www.xpj19688.com | www.38789b.com | j82365.com | www.pj1909.com | www.8998786.com | hg2272.com | www.41716e.com | www.679by.com | vns9028.com | www.625207.com | www.ya270.com | 184616.com | www.js892.net | www.187132.com | 111122jj.com | 98886508.com | www.333133u.com | ss5002.com | www.190619.com | cqgj2.com | 63522.com | www.4138i.com | www.js284.com | www.628987.com | long8801.com | t5666.com | www.668994.com | xin805.com | www.yzc329.com | gcgc04.com | www.g1996.com | www.7893w54.com | bm889900.com | 53516l.com | www.36788s.com | www.181472.com | www.2jsjs.com | www.43131v.com | www.97004.com | 352354.com | d61515.com | www.3099567.com | www.9374q.com | www.774468.com | www.oooo9927.com | www.36583333.com | 78556622.com | yl77636.com | 660023.com | k8md22.com | www.99933js.com | xf835.com | www.mgm7.com | www.33997j.com | jinshacheng01.com | ylg010.com | www.pj7795.com | www.745679.com | www.yh6008.com | 73807.com | vns6636.com | www.4323j.com | www.767065.com | 2820y.com | 6150d.com | www.y35pp.com | www.58505.com | t63568.com | www.pa888999.com | www.hx2088.com | www.9539005.com状态:OK | www.xh260.com | www.151pj.com | mgc6663.com | www.xhtd1349.com | heji135.com | hg6680.com | www.7111v.com | j7728.com | 1314xpj.cc | www.938751.com | i45638.com | www.5003rr.com | www.107625.com | 33302p.com | www.0343d.com | 3307111.com | 8901y.com | www.468667.com | www.cr339.com | www.38144144.com | www.20777744.com | www.yl99636.com | 442996.com | www.5095599.com | www.vnsr33888.com | www.k5753.com | 333808c.com | www.186371.com | www.17780001.com | 9566409.com | g57365.com | www.w8008.com | v6316.com | www.rb776.com | 8124m.com | 3136511.com | 31399m.com | www.9086v.com | www.y35uu.com | www.00618z.com | 3653501.com | www.6000vns.com | tai-in.net | www.n3065.com | www.32666f.com | www.132018.com | www.js476.com | 664006.com | cr36.com | www.68993271.com | long038.com | 778645.com | sss0062.com | 4186e.com | www.666405.com | web.fh6001.com | 7334nn.com | 33550007.com | www.943v.com | www.hgw002.com | 994194.com | www.c53889.com | 20550471.com | www.436689.com | www.weide555.com | 55886609.com | 86btt.com | 69yh76.com | www.hg0780.com | 66622008.com | sb6007.com | 088525.com | www.27111j.com | www.8839j.com | www.501571.com | beb001.com | bet79888.com | www.55952r.com | 188748.com | 345741.com | www.44kcw.com | www.wd6966.com | www.hg2239.net | wnsr298.com | 114375.com | www.647769.com | www.xpj19688.com | www.222xm.cc | www.507671.com | 1869u.com | 83365y.com | www.588038.com | 69666678.com | www.pjylc8888.com | www.398793.com | www.k8md05.com | 511111.com | 01112055.com | www.xpj7811.com | hg66006.com | www.534677.com | www.bbw33.com | www.08pj.com | www.99638d.com | www.55004138.com | www.hg250.com | 528213.com | www.875909.com | wxc877.com | vns8823.com | 505887.com | www.tai0011.com | www.35918r.com | 1549ss.com | wn879.com | 3355vn77.com | www.r7711.com | yd654.com | www.js70800.com | www.8582vv.com | www.77114111.com | www.866918.com | www.501043.com | 792433.com | www.028916.com | www.9740js.com | www.9997v.com | www.1933366.com | www.810706.com | www.y35999.com | 3388v.com | xpjdc018.com | www.933966.com | www.875307.com | m.vn66a.com | www.xh815.com | www.44554066.com | www.lswjs117.com | a12218.com | www.55777k.com | xpj9211.com | www.658056.com | y36uu.com | www.x4242.com | www.9595l.com | www.00829s.com | www.383089.com | www.65757q.com | h3678.com | www.66885002.com | d88dc07.com | www.df8x.com | www.134148.com | 9702w.com | 98957999.com | 167199.com | www.091069.com | hg50999.com | www.371h.cc | wd890.com | www.1466b.com | www.cx9872.com | www.dafa3.cc | ss29329.com | www.15365a.com | 67899900.com | www.142383.com | www.588588365.com | yl527.com | yifa0009.com | 114532.com | www.tlc823.com | js345vip.net | www.489901.com | www.041193.com | www.hv788.com | www.6609k.com | 3630g.com | www.0267v.com | www.bbo028.com | 28488822.com | www.178389.com | 99799bai.com | www.452815.com | hg0377.com | www.847677.com | z0088hg.com | www.sytg7.com | www.a1908.com | www.33598s.com | www.516163.com | www.004829.com | www.wwwab6.com | www.5zz66.com | www.5757hm.com | www.dafabetbogg.com | b33318.com | www.435776.com | www.e6861.com | www.777794.com | www.733350.com | www.bet6886.com | 6648dl.com | www.042055.com | www.lehu87.com | www.1434u.com | www.fh3007.com | www.42456688.com | www.bmw023.com | www.8582pp.com | rb8666.com | www.28462000.com | www.0893yh.com | www.6653k.com | www.018120.com | www.hg15588.com | www.5858b.cc | www.50054h.com | www.020261.com | www.535hc.com | www.hg559w.com | www.861150.com | 555789x.com | www.375736.com | www.038929.com | www.297126.com | www.28483300.com | 466196.com | www.1119685.com | www.pj7796.com | www.00852mmm.com | www.7555xpj.com | www.103566.com | www.kb8803.com | js881188.com | www.99159l.com | www.y833366.com | bet3658884.com | 99338040.com | www.760061.com | 917xpj.com | 29886p.com | www.9785555.com | www.95994455.com | www.3171d.com | www.bg17.cc | www.6678695.com | www.c93919.com | www.hx1163.com | hg3400.com | www.1880205.com | www.www9411jj.com | www.327160.com | vns8283.com | 3286k.com | www.01512288.com | www.50483.cc | www.8091888.com | 297920.com | 398438.com | 149606.com | www.555550907.com | hg8494.com | www.5589555.com | 985706.com | 25288c.com | 1423huang.com | www.xj1996.com | www.a8399.com | www.550415.com | 618804.com | 8167g.com | www.7085888.com | www.s8s222222.me | www.vns9890.com | www.bt292.com | www.836666x.com | www.349699.com | vns33.me | 15566008.com | www.fei27.com | www.p55155.com | www.hg4058.com | 537002.com | 618s.cc | www.yli33.com | 999365.tv | www.pj7798.com | 767258.com | www.11099.com | rb322.com | www.876295.com | www.79788.com | www.063737.com | vns.online | www.yh9993.com | www.00405566.com | 06266a.com | www.hg3733.com | www.22933w.com | www.89798.com | www.210915.com | www.343527.com | 7908a.com | www.385670.com | www.v3064.com | www.789194.com | www.1389v.com | www.13666007.com | www.882358.com | www.xpj3386.com | heji999.com | www.js95959.com | www.hg179t.com | www.xpj7.net | 95997878.net | www.9646j.com | hg1813.com | www.66159j.com | www.vv710.com | www.yh6543.com | 6459888.com | 785989.com | www.4406132.com | www.021587.com | 99667y.com | hg97577.com | 1406766.com | 468277.com | msc67.com | rb2555.com | www.504377.com | www.8230998.com | 501501k.com | www.3049292.com | 050316.com | 7830y.com | 88jt77.com | www.328229.com | www.34545s.com | 28448888.com | www.328429.com | 55562055.com | www.787022.com | www.535639.com | www.vns9n9.com | www.yh87666.com | 918md04.com | wns505.com | 6882l.com | hg107.com | dhy8181.com | www.36787f.com | 38989qq.com | www.902025.com | www.t3652.com | 071797.com | www.s0311.com | q55667.com | 388348.com | xbl5.com | www.095222.com | www.caosi58.com | 3559c.com | www.771501.com | www.757118.com | wd088.com | www.1423jin.com | www.830423.com | www.283826.com | www.6465i.com | www.h72555.com | www.bvnsr.com | sb7800.com | www.xb8899.com | 66159n.com | 687060.com | www.915903411.com | www.309775.com | www.879nn.com | www.263585.com | 09y.cm | www.js1184.com | 5002ll.com | www.hgyz88888.com | ai01811.com | xw2211.com | www.1389ee.com | 8040.com | www.87669.com | 0088hg2.com | hg9816.com | www.7366009.com | vns8875.com | www.4238.com | www.70040404.com | bwin456.com | www.vnsr380.com | www.9435999.com | www.49956j.com | www.9411p.com | wjpy8.com | www.37447a.com | cqgj15.com | www.643552.com | www.900397.com | www.6660365.com | www.355325.com | www.757993.com | 262914.com | 1389v.com | 828m.cc | 6444555.com | www.4167i.com | 030f.net | xx1423.com | pj79955.com | www.511642.com | www.687112.com | www.3657708.com | www.55268qq.com | www.0082949.com | 4343234.com | v56877.com | 4541m.com | www.2408c.com | www.0329z.com | yun338.com | ylhg1818.com | 9294.cc | www.lehaofa99.com | 00217a.com | js33999.com | www.97171.cc | 2767u.com | 947365.com | www.ra222.com | www.h13666.com | 335607.com | www.js30188.com | bet8085.com | www.670665.com | www.440499.com | 7744iii.com | www.466799.com | www.r955.com | www.wd7999.com | www.sun035.com | www.770yh.com | bifa0088.com | 44665002.com | www.4138n.com | www.338057.com | www.hg77188a.com | dhy126.com | www.336034.com | xpj15595.com | www.153918.com | j3819.com | www.552038.com | www.99638h.com | 88528oo.com | www.203bet.com | www.144.com.tw | 55519t.com | ssss8080.com | www.918.com | www.6449z.com | www.bifa0066.com | www.090766666.com | 7081pj.com | www.330265.com | www.9568899.com | vns9078.com | www.54400s.com | www.u8811.com | 3136532.com | www.428585.com | xpj66866.com | 35306.com | www.54549944.com | www.944sun.com | wst2014.com | www.yh66606.com | www.hg559l.com | c38hh.com | www.91599u.com | www.rb614.com | 7722138.com | vns6619.com | 1314nnn.com | www-pj977.com | v0075.com | www.55114138.com | yatou888.com | 83377k.com | www.8898r.com | www.34788i.com | www.778709.com | 81849r.com状态:OK | www.270648.com | www.2000028.com | 634698.com | www.355225.com | 84898c.com | y8553.com | www.206881.com | www.mm0151.com | xjgw888.com状态:OK | www.038909.com | www.r4364.com | www.166237.com | www.178125.com | www.y6779.com | 99567s.com状态:OK | www.139733.com | www.bb7477.com | d0709.com状态:OK | www.195090.com | www.076399.com | 777501.com状态:OK | www.50080e.com | www.r7837.com | 556069.com | 306969r.com | yl9008.com | d9163.com | www.885527.com | www.058888g.com | 5183131.com | 8870am.com | eee5002.com | www.pj9333.com | oo656.net | www.yinhe608.com | c3065.com | www.374789.com | www.77528s.com | www.556556f.com | www.566367.com | www.ao899.com | am9886.com | www.vgs228.com | 4449193.com | www.xpjdc538.com | ok3365.com | www.ejylc12.com | 321087.com | 4776666.com | www.25688m.com | www.js1355.com | tai55.com | www.652982.com | www.betyoude.com | www.9599422.net | www-pj676.com | www.373022.com | tc7577.com | www.j72555.com | 7843tt.com | hg739907.com | hr2222.com | www.89hghg.com | www.0267s.com | www.wnsr299.com | www.86267c.com | 8000196.com | js1182.com | www.35155e.com | 33382jj.com | www.xin805.com | www.r3467.cc | www.longhu268.com | www.hg25886.com | www.630040.com | www.pj9654.com | www.393987.com | 0503cc.com | www.bai84.com | 97066003.com | www.97649.com | www.98958222.com | www.62288u.com | www.yh6167.com | 040401.com | www.j2367.com | 9176686.com | 7484l.com | www.979zf.com | 505587.com | 899279.com | www.8bd.com | www.145979.com | 5719.com | www.592771.com | www.y0009.cc | ylg6866.com | www.w11h.com | www.664664.com | www.688490.com | www.bet305i.com | www.889601.com | 22003955.com | 28482233.com | www.282723.com | www.376169.com | www.188030.com | ule327.com | www.bmw9968.com | www.900397.com | www.678471.com | yh066.cc | 55615d.com | yh1617.com | www.618dz.com | www.hg7811.com | 57800e.com | www.616524.com | www.d1345.com | 81138n.com | www.5999922.com | www.8167x.com | www.81306b.com | 533177.com | www.649508.com | 315509.com | www.2078p.com | 2528hh.com | 0670.com | www.055u.cc | 4364d.com | www.tlc0070.com | 295668.com | www.s22678.com | www.6609qq.com | 81980.com | 20160913.in | 66899x.com | www.tyc8566.com | bet365194.com | www.hx1162.com | www.yl12344.cc | www.9599488.net | j81888.com | www.090091.com | www.w9686.com | www.pjc33.com | 8167o.com | www.pj888c.com | www.02773b.com | vip.v1122.tv | www.106167.com | ee1423.com | hg2122a.com | www.772733.com | www.5522y.cc | y811177.com | www.20660g.com | 4988l.cc | www.917979.com | www.9854js.com | 4015678.com | 88465.com | www.y18kk.com | www.vns6433.com | www.0588j.com状态:OK | 7744yyy.com | www.xh118.com | xpj6881.com | www.678341.com | sb3111.com | www.yh76m.com | 27877v.com | www.620821.com | sz8222.com | www.018999s.com | hlf897.com | www.324838.com | www.80075u.com | www.wt599.com | tyc2217.com | 876445.com | www.142525.com | www.gd678.com | www.87880.cc | www.hg8454.com | www.239838.com | www.1414.net | 2000021.com | hg98069.com | www.239838.com | www.1423zhou.com | www.3412255.com | vns33085.com | www.50074i.com | www.95905p.com | 38989d.com | d4129.com | 2357.ca291.com | www.z0088hg.com | 9136686.com | www.jsjs118.com | 78555k.com | www.hg9812.com | www.57799pp.com | www.9539005.com状态:OK | g2260.com | 10ff8.com | 6625zz.com | www.43288l.com | 3u888.com | www.5859118.com | www.985705.com | www.k8md01.com | 809986.com | www.50051f.com | www.400888ll.com | ls0011.com | vip234365.org | www.550214.com | www.l2bb.cc | www.aomen5511.com | www.385080.com | www.110602.com | www.4107j.com | vns6656.com | q3854.com | www.wl09.com | www.50989f.com | v168.tv | hg91909.com | vn98803.com | www.974987.com | 4759oo.com | www.xpj272.com | 899396.com | md2lc8.com | www.ihg5522.com | www.00997136.com | www.hg0199.org | www.223135.com | 86188e.com | 1869t.com | 34567z.cc | www.709866.com | www.253738.com | www.t639.com | vns3033.com | www.mgm9515.com | www.97780088.cc | 55248811.com | www.x552.com | www.54443c.com | www.yzc575.com | yun7878.com | www.979233.com | www.1516pp.com | www.4433556.com | tyc7865.com | www.jz3888.com | www.pujing95.com | 0666.tw | www.362960.com | www.353926.com | 0032444.com | msc573.com | www.88669159.com | 8773077.com | www.m91365.com | m56222.com | 76907x.com | www.5436f.com | www.am1806.com | bcbm333.com | www.377183.com | www.h88857.com | www.321087.com | 4111hhhh.com | www.139970.com | www.3126b.com | www.22299199.com | xin888666.com | www.88528p.com状态:OK | 073144.com | www.22062a.com | www.www5002.com | 1495088.com | www.851034.com | www.209101.co | www.hg6634.com | www.23427r.com | www.mgm8517.com | vip1384.com | hv1818.com | www.6678579.com | www.v7983.com | xinhao88.net | c65335.com | www.461746.com | www.77114t.com | vns54688.com | www.dhy6690.com | 7771pj.com | 678793.com | www.7cpb.com | www.804234.com | www.hgbf-bbt.com | www.h666333.com | www.137787763.com | www.506729.com | www.7733qipai.com | 123410.cc | 20660s.com | gf9000.com | 5207801.com | www.22js66.com | www.55951j.com | www.hg2566.in | www.789242.com | www.53594455.com | www.169097.com | www.075228.com | www.w99927.com | 95zzgw5.net | www.780725.com | www.493356.com | www.hg5857.com | www.55618ju.com | www.n05558.com | 597570.com | 442678.com | www.q98478.com | www.311136.com | m8867.com | 050338.com状态:OK | www.18luckfafafa.run | www.lf888.club | www.yh66604.com | 35646666.com | www.50588kk.com | www.202176.com | www.454696.com | www.77802k.com | d6403.com | www.79498d.com | 5207807.com | www.314099.com |